AS-186 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase from Pencillium asperosporum KY1635.
نویسندگان
چکیده
منابع مشابه
Phenylpyropene A and B, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Penicillium griseofulvum F1959.
Acyl-CoA: cholesterol acyltransferase (ACAT, EC 2.3.1.26) is the primary enzyme responsible for intracellular esterification of cholesterol in intestinal mucosal cells, synthesis of the cholesteryl esters packaged into very-lowdensity lipoproteins (VLDL) secreted by liver, accumulation of cholesteryl esters within macrophages and smooth muscle cells of the atheroma, and plays a key role in form...
متن کاملInhibition of acyl-CoA: cholesterol acyltransferase by helminthosporol and its related compounds.
acyl-CoA and cholesterol. This enzyme plays key roles in both intestinal absorption of cholesterolX) and cholesteryl ester accumulation in macrophagederived foam cells, which are prominent in atherosclerotic plaques2). In the course of the search for microbial metabolites which inhibit cholesteryl ester formation in macrophages, helminthosporol (1)3), helminthosporal-derived acid (2)4) and helm...
متن کاملUpregulation of acyl-CoA: cholesterol acyltransferase in chronic renal failure.
Chronic renal failure (CRF) is associated with profound abnormalities of lipid metabolism and accelerated arteriosclerotic cardiovascular disease. In a recent study, we found marked downregulation of hepatic lecithin-cholesterol acyltransferase, or LCAT, expression, which can account for impaired HDL maturation and depressed HDL cholesterol concentration in CRF. Here, we report on the effect of...
متن کاملThe functional size of acyl-coenzyme A (CoA):cholesterol acyltransferase and acyl-CoA hydrolase as determined by radiation inactivation.
Frozen rat liver microsomes and rough endoplasmic reticulum were irradiated with high energy electrons. The surviving enzymatic activity of acyl-CoA:cholesterol acyltransferase and activity for esterification of 25-hydroxycholesterol decreased as a simple exponential function of radiation exposure, leading to a target size of 170-180 kDa. The loss of acyl-CoA hydrolase activity with a radiation...
متن کاملGERI-BP001 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase from Aspergillus fumigatus F37. I. Production, isolation, and physico-chemical and biological properties.
GERI-BP001 compounds, new inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT), were isolated from a culture broth of Aspergillus fumigatus F37 by acetone extraction, EtOAc extraction, SiO2 column chromatography, and reverse phase HPLC. GERI-BP001 M, A, and B inhibit ACAT activity in an enzyme assay system using rat liver microsomes by 50% at concentrations of 42, 94, and 40 microM, respec...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1994
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.47.16